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tina huang data scientist

Biol. 35, 15471549 (2018). Protoc. Quat. While terms such as lithic industry, techno-complex, prehistoric tradition, and so on might be more appropriate to refer to the various associated chrono-cultural subdivisions, they concern different levels of discussion and are not applicable to all contexts investigated here. Moreover, the almost complete genetic replacement of the Magdalenian-associated gene pool raises the hypothesis that parts of Europe were differentially populated during the abrupt climatic variation starting around 14.7ka with the BllingAllerd warming period, creating areas where southern European populations could expand. Curr. Home Courses Scoreboard Recommendations. In article number 2206752, Hao Zeng and co-workers report a soft actuator assembly capable of windassisted dispersal and lift-off/landing action under the control of a light beam.The design is inspired by the seed of dandelion, resembling several biomimetic features, i.e., high porosity, lightweight, and separated vortex ring generation under a steady wind flow. Lipson, M. et al. Data warehousing is a relatively new field that focuses on the use of large datasets for analytical purposes. & Vernot, B. The indexed products for each library were pooled, purified over MinElute columns (Qiagen), eluted in 50l TET and again quantified using the IS5 and IS6 primers59 using the quantification method described above. In this case, the data is being loaded from the MySQL database. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness . Fu, Q. et al. Rivollat, M. et al. Extended Data Fig. is supported by a Ramn y Cajal fellowship (RYC-2017-22558). However, published Gravettian-associated genomes originate from central and southern Europe, leaving the genetic profile of Gravettian-associated humangroups from western and southwestern Europe undescribed. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. First Name Tina #39. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. 2 The distribution of mtDNA and Y-chromosome haplogroups among different hunter-gatherer groups. USA 116, 16391644 (2019). Ecol. Riddle Solved: Why Was Roman Concrete So Durable? Big Data, Data Mining, and Machine Learning (Jared Dean) . Details of the modelling are provided in Supplementary Data 3.E,F. PubMed Central Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. The genetic prehistory of the Baltic Sea region. Lifetime access to all course materials and updates. Article ather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. Alexis Bledel. S. Shnaider received support from theRussian Science Foundation (no. Genetically, however, the populations from western and southwestern Europe (today's France and Iberia) differed from contemporaneous populations from central and southern Europe (today's Czech Republic and Italy). I am super excited to join the 365 Data Use Cases series, and in this post, I will share insights about my favorite data use case: product development. The idea of data warehousing is to store large amounts of data in a way that makes it easier to extract and analyse. Fifth, the Oberkassel ancestry in western and central Europe and the Sidelkino ancestry in eastern Europe remained largely isolated for almost 6,000 years until genetic interactions were first observedaround 8ka in northeastern Germany, possibly associated with cultural exchanges along the Baltics49 and around 7.5ka in the upper Volga region, possibly linked to the spread of pottery in the region50. Track your course progress, set daily goals, and make success a routine. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. A hands-on course covering SQL setup and fundamental components, combined with a guided walkthrough of 10 mock interviews with real-world SQL interview questions and expert tips on how to pass them successfully. Here is a sampling of five herbs that have demonstrated potential immune support benefits: 1. Big data data warehousing and data science are two sub-tasks of a larger endeavor . Despite this wide geographical range, it is not clear whether different groups associated with this culture originated from a common source population and how those groups were genetically related to each other. Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). In the MDS plot, we find that all of the newly and previously reported Epigravettian-associated individuals fall within the Villabruna cluster4 (Fig. & Posth, C. Latest trends in archaeogenetic research of west Eurasians. Admixture events were dated using the ancestry covariance pattern-based DATES 753 program105, with a bin size of 0.1 cM for covariance calculation and the start of exponential fitting at d0.5cM. I help students become independent data scientists who are not just good at data analysis, but are also able to think about their own learning and the world around them. PubMed The Sidelkino ancestry also emerged around 14ka with its first direct evidence in eastern Europe43 dated to 13ka. The incoming Villabruna ancestry later became the most widespread hunter-gatherer ancestry across Europe. (eds. The ROH segments in hunter-gatherer genomes were identified using hapROH101. Dots are maximum likelihood estimates and error bars show 95% confidence intervals of the derived allele frequencies (n, the number of individuals in each group, is provided in Supplementary Data 3.G). & Steinrcken, M. Parental relatedness through time revealed by runs of homozygosity in ancient DNA. Genetic ancestry changes in Stone to Bronze Age transition in the East European plain. The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis occurs. Hi, my name is Tina and I'm a data scientist at a FAANG company. The 3 Greatest Moments in science library uga hours History, Addicted to hills science diet adult small bites? Meyer, M. & Kircher, M. Illumina sequencing library preparation for highly multiplexed target capture and sequencing. 39, msac017 (2022). Evol. S.T. Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. She graduated with a degree in Computer Science and Applied Math. Her main topic is AI, exploring how it works and, most interestingly, how we increasingly interact with it in the world. All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. A recent bottleneck of Y chromosome diversity coincides with a global change in culture. First Name Tina. Required fields are marked *. OUR UNIVERSITY Our University . Protoc. Also if you want to see some cat pics. 14, evac045 (2022). Tina has an MSc in Computer Science from the University of Pennsylvania, and an HBSc in Pharmacology from the University of Toronto. Extended Data Fig. In sum, we describe the formation and interaction between the Oberkassel and Sidelkino clusters, the two main hunter-gatherer ancestries present in Europe from 14ka onwards. "At that time, hunter-gatherers with distinct ancestries and appearances started to mix with each other. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. From AI YouTubers to accessibilityadvocates. Nowadays, we take it for granted that these features exist, but the integrity of those products is, in fact, a labor of love. Packed with 10 mock-up interviews with real life questions, this course provides you with the expert walkthrough you need to feel at ease showing your SQL knowledge, along with helpful tips on how to and recover from mistakes quickly and gracefully, prepare for follow-up questions, and remain calmduring the interview. Data mining is the process of finding patterns in large amounts of data. Article ISSN 1476-4687 (online) Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. ), Science . The deduplicated bam files were filtered using PMDtools 0.6068 with a threshold of 3, to reduce potential modern DNA contamination based on postmortem DNA deamination. Previously worked at Goldman Sachs and the Ontario Institute for . As a general rule of thumb, we start from the simplest issue and gradually increase in complexity. This is one of the things that make us stand out from other platforms which usually consider mathematics and statistics a prerequisite. Otte, M. Appearance, expansion and dilution of the Magdalenian civilization. After merging, individuals with less than 6,000 SNPs on 1240k sites were excluded from further analysis because of low coverage. Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. Double-stranded DNA libraries were built from 25l of DNA extract, without the presence of uracil DNA glycosylase (ds_nonUDG) or in the presence of uracil DNA glycosylase (ds_halfUDG), following a double-stranded UDG-half library preparation to reduce, but not eliminate, the amount of deamination-induced damage towards the ends of ancient DNA (aDNA) fragments58. 2. Cosimo Posth, He Yu or Johannes Krause. Conversely, individuals in the Sidelkino cluster are genetically closer to AG3 than Tutkaul 1. Dr. Huang taught General Chemistry, Quantitative Analysis, and Instrumental Methods for eight years at . In addition to this general data science content, Tina teaches SQL . 1), we used pathPhynder99 based on the tree from Karmin et al.100. In this period, the Oberkassel-ancestry admixture spread further east, reaching Samara by around 6.5ka, and an increase in Sidelkino ancestry was detected in hunter-gatherers from the Baltic region, which was previously associated with the transition from the Narva culture to the Comb Ceramic culture38,39 (Extended Data Fig. We further tested whether individuals included in the Vstonice and Fournol clusters share similar allele frequencies with the main representatives of those two clusters. Contact Us. Tina Huang. B. et al. Curr. Proc. 8). 6). Chintalapati, M., Patterson, N. & Moorjani, P. The spatiotemporal patterns of major human admixture events during the European Holocene. This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). Similarly, the SMS spam collection data achieves 99.20% for the validation and 99.10% for testing. The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. Quat. Sci. . This figure shows that the Gravettian-associated individuals from western Europe (Fournol cluster) are closely related to Goyet Q116-1 while the Gravettian-associated individuals from central-eastern and southern Europe (Vstonice cluster) are closely related to the Sunghir group, representative of the Kostenki cluster. Reads with a mapping quality below 30 were then filtered with samtools, and the consensus sequences were generated by Schmutzi69. As she gains working experience with one of the FAANG companies, Tina continues to share interesting details about her career journey with the audience. 101019659 (to K.H.). The long-lasting genetic continuity in Iberia is also reflected in the preservation until the Mesolithic of Y-chromosome haplogroup C, which was predominant in pre-LGM groups but rarely found after the LGM in other parts of Europe (Extended Data Figs. The pathway program not only helps students to strengthen their English, but more importantly, it helps students to understand and adapt to the expections of university.". The mitochondrial capture sequencing reads were cleaned by AdapterRemoval 2.2.0 to remove the adapters and reads with lengths below 30bp. Her YouTube channel advises data science jobs, self-study, boosting productivity, resume reviews, etc. 1, Extended Data Table 1, Supplementary Data 1.A, Supplementary Information, section1 and Supplementary Fig. 2022 Weird Science Plus - All Rights Reserved. ADS 6, 16581668 (2022). Natl Acad. I admit, i was too confident in my SQL, however that changed after seeing the interview questions that could be asked from different angle, the most important thing i have learnt in this course is CTE, and her Sunday SQL videos on YouTube is icing on cake. Meet Tina Huang. Overall, the literature suggests that Chinese Canadian students demonstrate high levels of achievement and that this academic success is associated with factors such as stronger feelings of ethnic identity, better English language skills in the family, Chinese . Its like the different ingredients in your recipe. This channel is about data science, learning, and productivity. This is also validated by f4-statistics of the form f4(Mbuti, Zlat k; test1, test2), which are consistent with zero for all other pre-LGM hunter-gatherers (Supplementary Data 2.C), indicating an equidistant relationship of Zlat k to the tested groups. 5 Summary of ROH segments detected in Eurasian hunter-gatherers. In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. The oldest individual revealing an indistinguishable genetic profile from the Yuzhniy Oleniy Ostrov group is the 11ka Sidelkino individual from Samara in western Russia42. My name is Tina and I'm a data scientist and YouTuber. Brunel, S. et al. 4. Overall, the Solutrean-associated Le Piage II individual links the preceding Fournol ancestry with the succeeding ancestry found in El Mirn, providing direct evidence for genetic continuity throughout the LGM in southwestern and western Europe. Culturally, however, we see both widespread general tendencies, such as weaponry and some portable art48, and other aspects that have a more regional character, such as mortuary practices (Supplementary Information, section13), various originalities in lithic and hard organic materials tool kits and adornments20,21. By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. This button displays the currently selected search type. Ancient admixture in human history. | pros vs cons. C. Posth, H.Y., A.G., A.B.R., W.H. Natl Acad. A draft sequence of the Neandertal genome. A Passive Flier. Nat. Antiquity 91, 573588 (2017). Highly Influential Citations 3. View Tina_Huang_Resume_i.pdf from HCI 445 at DePaul University. Gonzlez-Fortes, G. et al. This might have been in part triggered by the concomitant expansion of Neolithic farmers across Europe and/or by environmental factors, such as the climatic event around 8.2ka, the largest abrupt cooling in the northern hemisphere during the Holocene epoch46,47. Besides, the nucleolus is involved in a variety of cellular functions including cell cycle regulation and cellular stress response. H. Rougier, I.C., L.K.,A. Morala, M. Ru, S.M., L.C., J.-B.C., E. Bocaege, S. Ricci, F.B., P. Bayle, B.M., F.L.B.-R., J.-G.B., G.O., E. Bortolini, O.B.-L., G.D., M.O., A.Z., V.S., E.S., L. Sineo, J.v.d.P., L. Pecqueur, G.M., G.G., J.-M.L., C.B.G., A.G.-O., M.P.-B., D.B., M.L.L., P. Storm, C.H., J. Kabaciski, T. Filimonova, S.Shnaider, N.B., B.G.-R., M.R.G.M., A.B.M.-A., B.L., C.A.-L., A.R., C. Polet, I.J., N. Cauwe, J.Soler, N. Coromina, I.R., R.C., G. Clark, L.G.S., M.-A.J., S. Rehart, D.T., S.B., M. Romandini, L.A., H. Bocherens, C.W., S. Villotte, J.F.-L.d.P., M.G.-P., M.A.E.-B., P. Bodu, L. Smits, B.S., R.J., J. Kozakait, C.C., H. Benthien, K.W., R.W.S., S.C.F., T. Schler, C.T., D.G., F.L., A. Kotula, H.P., F.S., J.Svoboda, S.Szelov,A.C., A. Khokhlov, N.J.C., F.V., K.H., P. Semal, B.J., A. Suvorov, R. Schulting, V.M., K.M., A.B. The formation of human populations in South and Central Asia. This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). Hi! Remember, its the problem that defines the tools we use! PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. For individual heterozygosity calculation, we also called pseudo-diploid genotypes from each library, using pileupCaller 1.4.0.3 under random diploid calling mode and the same strategy for different types of libraries as pseudo-haploid genotype calling. PubMed 12). Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Huang's parents immigrated to New York City where her two older brothers . Join a growing community of 11K+ to find accountability partners, take part in productivity sprints, and join discord only events! Thank you for visiting nature.com. The genetic affinity to the Villabruna ancestry is present in El Mirn and in Magdalenian-associated individuals from western and central Europe. Become the most confident candidate in the room. Biol. Ancient genomes indicate population replacement in Early Neolithic Britain. Extended Data Fig. Moreover, we reveal a north-to-south decrease in genetic diversity among the Epigravettian-associated groups, with the highest PMR and heterozygosity values found in northern Italian individuals (group 1), intermediate in western and central Italian individuals (group 2) and the lowest in Sicilian individuals (group 3) (Fig. Learn in-demand skills with a structured course that prepares you for the world of data science as it is today. A similar pattern is observed through the analysis of ROH segments (Extended Data Fig. Bioinformatics 29, 16821684 (2013). Sci. Notably, this genetic distinction coincides with dissimilarities in mortuary practice among genetically analysed Gravettian-associated individuals from different parts of Europe. Genetic sexing revealed 78 maleindividuals and 38 femaleindividuals (Supplementary Fig. B 370, 20130624 (2015). Google Scholar. Ancient Rome: A genetic crossroads of Europe and the Mediterranean. The code for the newly developed ROH based contamination estimate method is available at https://github.com/hyl317/hapROH. Nat. Lead Advisor - Data Science. mtDNA capture63 was also performed for those libraries where mtDNA coverage was not high enough to assess mtDNA haplogroup and contamination. October 28 Actress #31. Check out Do Deepfakes Have Fingerprints? I'm I've learned SQL before, but I need a refresher. Tina teaches SQL in data science in addition to this basic material. . Moreover, none of the Epigravettian-associated individuals have more affinity to southern European than to central-eastern European Gravettian-associated groups, as shown by f4(Mbuti, Epigravettian-associated individual/group; Vstonice, Paglicci 12) that is consistent with 0 (Supplementary Data 2.G). YourCourse Certificatehas no expiration date. W jednej z historii misiaczki za rad pewnej wydry zamieszkuj w tajemniczym . assembled archaeological material, descriptions and interpretations. "Ice Age survivors." Dabney, J. et al. Petr, M., Pbo, S., Kelso, J. In addition to her data science work, Tina has also created the popular popular game Code Wars. The newly reported individuals with over 15,000 SNPs on the Human Origins dataset are shown in black-outlined and filled symbols, as illustrated in the legend on the right, while representative ancient genomes are shown in outlined symbols, as illustrated in the legend at the bottom of the PCA. They, along with it, will be accessible to you indefinitely. They were different in many aspects, including their skin and eye colour," says He Yu. Once we have the data, we begin to tease out the high-impact insights. 3, 765771 (2019). Theyre both important sub-tasks for data scientists to master, but big data data warehousing and data science are only two components of the larger data science endeavor. Nature (Nature) Gnther, T. et al. For the DNA lysis, a solution of 900l EDTA, 75l H2O and 25l proteinase K was added. Dismiss. K.N., V.V.-M., R.R., T. Ferraz, R.T., D.G.D., M.L., A. Modi, S. Vai, T. Saupe, C.L.S., G. Catalano, L. Pagani, D.C. and E.A. 40, e3 (2012). Google Scholar. 4, 324333 (2020). Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracilDNAglycosylase treatment for screening of ancient DNA. 2011. By using our site you agree toour Nature 505, 8791 (2014). About me. You have to deal with large datasets; however, you have to do your work in a way that makes sense to your team. b, Population diversity shown by PMR between individuals in different groups. Floor Coatings. https://doi.org/10.1038/s41586-023-05726-0, DOI: https://doi.org/10.1038/s41586-023-05726-0. We thus modelled individuals belonging to the GoyetQ2 cluster and El Mirn as a mixture between the Fournol 85 and Arene Candide 16 genomes as proxies to represent the Fournol and Villabruna ancestries, respectively, in Magdalenian-associated groups (Fig. Thats exactly why choosing the right feature to build is so important! El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). Don't be shy, get in touch. "Ice Age survivors." A negative and cave bear positive controls were included. The phylogenetic reconstruction of Epigravettian-associated genomes, with Pradis 1 diverging more deeply than all others, indicates that the turnover took place much earlier than 17kathe date of the more derived Tagliente 2 genome. Genetic analyses of western European individuals associated with the preceding Badegoulian culture might provide clues on the processes that led to the formation of the GoyetQ2 cluster. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. Unlike setting up a Premium subscription to our platform, for which you would be billed monthly or annually, acquiring individual courses requires a one-time payment only. The end goal is to create and grow a product that users love. When expanded it provides a list of search options that will switch the search inputs to match the current selection. (grey) of the f4 values estimated from 5cM-block jackknife analysis. It is not intended to provide medical or other professional advice. 3.Tina Huang. Here we will provide you only interesting content, which you will like very much. Cuando se ampla, se proporciona una lista de opciones de bsqueda para que los resultados coincidan con la seleccin actual. The science policy "Framework for Federal Scientific Integrity Policy and Practice" issued by the White House Office of Science and Technology Policy a day later is criticized as a "gag order" on scientists by PEER in an open letter (30 Jan). 2c). Sci. This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka). Finally, unsupervised clustering and more complex techniques, such as deep learning, also have their place. 9, 442 (2018). Evol. Genetics and material culture support repeated expansions into Paleolithic Eurasia from a population hub out of Africa. Powered by Symplectic part of Digital Science . Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers. Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry. Brace, S. et al. Think about some of your favorite apps today: Instagram, Uber, Facebook, and YouTube. English company number 3898053New York | Boston | Chicago | Austin | Toronto | Brighton | London | Copenhagen | Berlin | Stuttgart | Frankfurt | Paris | Madrid | Budapest | Sofia | Chennai | Singapore | Sydney | Melbourne. I also have a newsletter called Boop's Keyboard! The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. In panel b, the colour code does not imply archaeological similarities. Sci. Bioinformatics 25, 17541760 (2009). Harris, K. & Nielsen, R. The genetic cost of Neanderthal introgression. 14), most post-14ka individuals from western and central Europe fall close to the WHG cluster and those from eastern Europe close to the EHG cluster, whereas the Tutkaul 1 individual from central Asia falls close to the ANE-related group. 7 Admixture dates between Oberkassel/Villabruna and ANE ancestries in the oldest individuals from the Sidelkino cluster. Survival of Late Pleistocene hunter-gatherer ancestry in the Iberian Peninsula. Proc. Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. As of right now, it doesnt seem that MySQL is the right choice for storing data because the database is so large, it would be impossible to find and query the necessary information. Nature 513, 409413 (2014). This was achieved through collaboration with local curators and scientists from the countries where the skeletal material is preserved and who are listed among the authors of this study. About the author: Tina Huang is a data scientist at one of the FAANG companies. Ecol. Save my name, email, and website in this browser for the next time I comment. Narasimhan, V. M. et al. Other proposed climatic refugia for human survival during this period are the Italian peninsula, the Balkans and the southeastern European Plain, but the actual genetic contribution of populations from these regions to post-LGM Europeans is highly debated11,12,13. A. Stoessel performed CT scanning and advised on sampling strategy. Tina Huang, born on October 28, 1981, is an American stage and television actress of Taiwanese descent known for her recurring roles in Rizzoli & Isles and for her semi-regular role as Melinda Trask on the NBC soap Days of Our Lives. 3,528. My name is Tina Huang and Im a data scientist at a FAANG company. One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. By contrast, the Goyet Q116-1 genetic profile gave rise to the newly described Fournol cluster identified in Gravettian-associated individuals from western and southwestern Europe. PubMed Central 3a and Supplementary Fig. For consistency with the previously discussed nomenclature, we rename the EHG ancestryas the Sidelkino cluster(hereafter, Sidelkino cluster or ancestry). . Nat. Further information on research design is available in theNature Portfolio Reporting Summary linked to this article. AMAZING COURSE! Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics.

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